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Another trial randomised older adults to healthy eating, hypocaloric diet, or very-low energy diet (VLED) groups, found that all diets improved cardiometabolic risk markers and reduced the number of people requiring T2D and CVD prevention medication, especially with VLEDs [62]

The reasoning relates to growth hormone physiology

Cagrilintide is notable for its role in combination research with semaglutide (the CagriSema combination) which has shown additive weight reduction effects versus either compound alone in Phase 2 trials