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The clearance time courses for dihexa and the standards fit curves defining single-phase exponential decay processes with an R 2 values between of 0.96 and 0.99 (Figure 34)

Warning signs include severe, persistent abdominal pain that radiates to the back, nausea and vomiting that do not resolve, and tenderness in the upper abdomen

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The external advisers ultimately determined there was enough evidence to conclude that eflornithine hydrochloride (DFMO) boosts event-free survival in pediatric patients with high-risk neuroblastoma