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Through injection of -syn preformed fibrils (PFFs) into the striatum of transgenic mice, researchers demonstrated the development of Lewy pathology, nigrostriatal degeneration, and importantly expanded our understanding of cell-to-cell transmission by describing the nature of spread in neuroanatomically connected regions: this provided the first evidence that synthetic -syn PFFs alone can induce the initiation and propagation of -syn pathology in vivo (Luk et al., 2012)

To investigate the combined effect of SNX1 and SNX2a on membrane deformation, we purified the SNX1-SNX2a complex (Fig

The effects of smoking and zinc on the oxidative reactions of human neutrophils

The autism-associated MET receptor tyrosine kinase engages early neuronal growth mechanism and controls glutamatergic circuits development in the forebrain