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Tesamorelin (Egrifta, and the later reformulations Egrifta SV and Egrifta WR) is indicated to reduce excess visceral (abdominal) adipose tissue in patients with HIV-associated lipodystrophy a condition in which antiretroviral therapy and HIV itself drive an abnormal accumulation of deep abdominal fat

Its -phosphate forms water-mediated hydrogen bonds with Met40, Gly41, and His47

Reprod Biol Endocrinol 22(1):83 Moustakli E, Zikopoulos A, Skentou C, Bouba I, Tsirka G, Stavros S et al (2023) Sperm mitochondrial content and mitochondrial DNA to nuclear DNA ratio are associated with body mass index and progressive motility