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In addition, as myofibroblasts are sensitive to matrix stiffness, developing strategies that reduce the pathological stiffness or alter the mechanical cues of the ECM in a way that deactivates myofibroblasts without disrupting ECM scaffolding needed for fibroblast migration and functional integrity

NR elevated hepatic NAD + by more than fourfold, peaking at 6 h post-gavage [12], suggesting that oral NR has different hepatic pharmacokinetics than oral NAM and NA