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Efficacy and safety of ultrahigh-dose methylcobalamin in early-stage amyotrophic lateral sclerosis: a randomized clinical trial

doi: 10.1007/s10147-016-1045-2 46 DurinckKGoossensSPeirsSWallaertAVan LoockeWMatthijssensFet al

For instance, as learned by X-ray crystallographic studies of complexes of the enzymes with glutathione alkyl thioethers as non-covalent inhibitors, in human class glutathione transferase A1-1 the sulphur atom forms a hydrogen bond to the hydroxyl group of a tyrosine and to the guanido group of an arginine [130,131,132]