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While the stinging and irritation associated with GHK-Cu injection is almost always benign and technique-related, it is useful to distinguish between normal injection site reactions and signs that warrant closer attention

However, the clinical benefit of this modality has still been limited due to several defects such as adverse events, acquired drug resistance, tumor recurrence, and lack of validated biomarkers, which impel further research on mechanisms of tumor angiogenesis, the development of multiple drugs and the combination therapy to figure out how to improve the therapeutic efficacy

Their potential mechanisms involve regulating glucose and lipid metabolism, correcting hormonal imbalances, attenuating oxidative stress and chronic inflammation, and beneficially modulating gut microbiota composition

This review is to accelerate the development of novel natural and herbal medicine treatments and to offer novel perspectives on how to treat ferroptosis in stroke