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These symptoms include insomnia, nervousness, elevated heart rate and tremors

and (3) decreased expression of anorectic cytokines

The patients with cblC were treated with hydroxocobalamin (OHCbl) (1 mg/day, intramuscular injection), betaine (100500 mg/kg/day, oral administration), folic acid(50 mg/day, oral administration),vitamin B6 (1030 mg/day, oral administration), sodium benzoate(150250 mg/kg/day, improve hyperammonemia), levocarnitine (50 mg/kg/day, oral administration), low protein and high-energy diet to reduce the accumulation of toxic metabolites

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