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Chapter: Basic & Clinical Pharmacology : Pharmacokinetics & Pharmacodynamics: Rational Dosing & the Time Course of Drug Action Basic & Clinical Pharmacology : Pharmacokinetics & Pharmacodynamics: Rational Dosing & the Time Course of Drug Action Half-Life - Pharmacokinetics Half-Life Half-life ( t 1/2) is the time required to change the amount of drug in the body by one-half during elimination (or during a constant infusion)