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Clinically, urinary IL-18 (uIL-18) is a highly sensitive early biomarker, typically rising prior to SCr changes [233]

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Your doctor will consider the following indications to help make this decision: Two or more gout attacks within the span of 12 months A history of kidney stones Chronic kidney failure Bone erosion on x-ray Presence of tophi (uric acid crystals under the skin pronounced toe-fi) When working with you to lower your bloodstream uric acid levels, your doctor will want to help you reach the following target uric acid levels in your bloodstream

[Google Scholar] [PubMed] Wu H, Feng K, Zhang C, Zhang H, Zhang J, Hua Y, Dong Z, Zhu Y, Yang S, Ma C (2021)