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[5] Jastreboff AM, et al

DSIP typically shows the fastest results, often improving sleep within 2-3 nights

In APP/PS1 mice, it reduces pSTAT3-positive astrocytes near plaques and enhances microglial morphological complexity, though amyloid clearance effects remain limited (277).AG490, a JAK2 inhibitor, reduces STAT3 phosphorylation