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Description

Biochem Pharmacol 2000

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Tesamorelin's mechanism follows the physiological GHRH signaling cascade: GHRH receptor binding : Tesamorelin binds the GHRH receptor (GHRH-R), a G-protein-coupled receptor expressed primarily on anterior pituitary somatotrophs cAMP-PKA pathway : GHRH-R couples to Gs proteins, activating adenylyl cyclase and increasing intracellular cyclic AMP (cAMP)