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Berberine: Botanical occurrence, traditional uses, extraction methods, and relevance in cardiovascular, metabolic, hepatic, and renal disorders

Additionally, ROS promotes pro-inflammatory signaling (e.g., NF-B activation) and endothelial adhesion molecule expression (e.g., VCAM-1, ICAM-1, TNF-), further exacerbating vascular stiffness and atherosclerosis (Zeng and Yang, 2024)