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Nature 464(7285):5965 Quigley EM (2016) Leaky gutconcept or clinical entity

GAD-SD, GAD antibody-spectrum disorders

The positive control was preincubated with DNAse (0.2 U/L) for 1 h at 37 C, and the negative control was incubated in the absence of the deoxynucleotidyl transferase enzyme

In cases of abnormal cellular iron metabolism, the excess accumulation of iron prompts intracellular accumulation of reactive oxygen species and lipid peroxidation, resulting in the degradation of cellular constituents such as lipids, DNA, and proteins (Koleini et al., 2021) (Figure 1)