glutathione hazards system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis Glutathione deficiency and heart failure:

American College of Chest Physicians and Canadian Thoracic Society 2015 85 : N-acetylcysteine treatment for patients with moderate to severe COPD and a history of 2 or more exacerbations during the previous 2 years. Conclusions COPD is clearly associated with an excessive lung oxidant burden and the rationale for exploring antioxidant therapies in this patient population is strong

Oxidized forms of ergothioneine are substrates for mammalian thioredoxin reductase

Because depletion of GSH induces apoptosis due to excessive oxidative stress [91], normal glutamine metabolism plays a critical role in preventing apoptosis by providing glutamate required for maintaining normal GSH/GSSG ratio

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