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Currently, activating key innate immune pathwaysparticularly the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathwayhas emerged as a promising strategy to enhance antitumor immune responses [8,9,10,11,12,13,14,15,16,17]

Petroff D, Blank V, Newsome PN, ShalimarVoican CS, Thiele M, deLedinghen V, Baumeler S, Chan WK, Perlemuter G, Cardoso AC, Aggarwal S, Sasso M, Eddowes PJ, Allison M, Tsochatzis E, Anstee QM, Sheridan D, Cobbold JF, Naveau S, Lupsor-Platon M, Mueller S, Krag A, Irles-Depe M, Semela D, Wong G, Wong VW, Villela-Nogueira CA, Garg H, Chazouilleres O, Wiegand J, Karlas T

The therapy is generally recommended to fit patients in the second line, especially to ease symptoms or as a bridge to targeted treatments within or outside of clinical trials

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