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This dramatic attrition underscores not only methodological deficits, such as inadequate randomization, absence of blinding, and insufficient statistical power, but also systemic issues in model validity and disease representation

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These nanocarriers function as protective matrices, isolating sensitive BACs from deleterious external conditions, enhancing their dispersion in aqueous media, and improving their physicochemical stability (16, 17)

Subacute combined degeneration of the spinal cord from untreated B12 deficiency causes demyelination of the posterior and lateral columns, leading to permanent weakness, balance impairment, and sensory loss