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Description

7.3.6 Clinical translation Successful translation of ferroptosis-targeted therapies requires methodical progression through several key stages: validation of candidate biomarkers in well-characterized human cohorts, optimization of inhalation formulations for consistent pulmonary deposition, and demonstration of safety and efficacy through rigorously designed clinical trials

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Compounds that bind iron, such as ciclopirox olamine (CPX), DFO, and deferiprone (DFP), inhibit ferroptosis by chelating iron ions and subsequently reducing ROS production (206, 207)

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