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Double-label immunofluorescence staining showed co-localization of IL-6 with F4/80 confirming that infiltrating macrophages during CP are an important source of IL-6 production and that macrophages play a role in the progression of pancreatic fibrosis ( To investigate whether the increased macrophages in the CP pancreas are mainly M1 or M2, CD11b monocytes/macrophages were selected for gene expression analysis in a mouse CP model induced by cerulein and further validated by flow cytometry that M2 macrophages, which are mainly anti-inflammatory and promote tissue repair, were predominant in CP ( In an in vitro assay, Xue et al

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