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As far as CHIC is concerned, syringomyelia is not a problem in the breed, and any cavalier may be bred without testing for it, much less found not to have it

Eur J Endocrinol 170(6):R241R252

Regarding safety, common adverse events of tofacitinib include herpes zoster infections, hypercholesterolemia, venous thromboembolism (VTE), and cardiovascular events

American association of clinical endocrinologists and American college of endocrinology guidelines for management of growth hormone deficiency in adults and patients transitioning from pediatric to adult care