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From the selected studies, the following data were extracted: first authors name, publication year, sample size, study location, mean age of participants, intervention (type, dose, and duration of supplementation), study design and end-point values (as means and sd) for the number of follicles, endometrial thickness, TT, progesterone, serum LH levels, serum FSH levels, E2 and SHBG in both intervention and control groups

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Postbiotics were stored at 20 C in sterile, airtight containers to preserve their bioactivity for subsequent analyses and applications

Statistical Design The study was designed to detect a difference of 0.5 standard deviation (SD) in the change (baseline to week 4) of average fatigue between the two arms, with 85% power, assuming an intrapatient correlation of 0.5, using a Wilcoxon-Mann-Whitney test with a two-sided type I error of 5%