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Description

The midstream segment involves the biomanufacturing process

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Nonphotic entrainment of the human circadian pacemaker

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The interplay between twelve hallmarks characterizes this process: genomic instability, telomere attrition, epigenetic alteration, loss of proteostasis, altered macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intracellular communication, chronic inflammation and dysbiosis 6,7

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