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Proton magnetic resonance spectroscopy ( 1 H MRS) provides an opportunity for in vivo evaluation of glutamate-related metabolites, depending on field strength and signal-to-noise ratio, glutamate and glutamine can be quantified either separately or as a composite of glutamate, glutamine, GABA, and other metabolites (most often labeled as Glx) (265)

However, medical professionals should always be consulted to assess the need for this form of therapy and monitor its efficacy and safety

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Results Activation of CDK5 in response to HG coupled with the induction of ER stress via the down regulation of sarcoendoplasmic reticulum calcium ATPase 2b (SERCA2b) gene expression and reduced the nuclear accumulation of pancreatic duodenal homeobox 1 (PDX1) leads to -cell apoptosis