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As a result of this tight interplay between insulin action and cholesterol homeostasis, other studies have evidenced that IR may imprint profound disturbances in the profile of steroid hormones and bile acids [21, 49]

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Curcumin has demonstrated anti-inflammatory properties, with small trials suggesting efficacy comparable to NSAIDs for osteoarthritis [92, 93]

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This observation raises the intriguing possibility that similarly to bacteria, polyP production in mammalian cells is directly linked to changes in cell metabolism and environment and that diminished polyP synthesis observed in HF myocytes results from the complex remodeling processes during cardiac hypertrophy and HF

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