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Description

J Neurosci Res 2006

GSH-activated prodrugs, including disulfide- and diselenide-linked conjugates, are selectively activated in tumors, enabling high drug loading and targeted delivery

A possible explanation is suggested by the emerging paradigm that the disulfide proteome consists of two subproteomes: a structural group and a redox-sensitive group (Yang et al., 2007)

As a preliminary matter, we notice that FDA declined to consider review articles on the ostensible basis that they present no new empirical data for consideration