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Nature 485 646650

New concepts in the immunopathogenesis of human immuno deficiency infection

For example, during the early stages of AD, deoxycholic acid accumulates in the brain and can directly impair cognition by binding with the bile acid receptor Takeda G protein-coupled receptor 5 (TGR5) on excitatory neurons, leading to STAT3 phosphorylation, Aph1 transcription, and increased A production [220]