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Figure 4 Hoane et al

We applied L-NAME (5 mg/kg), L-arginine (100 mg/kg) given per se or combined with each other, intraperitoneally, at 30 minutes before amputation

In these circumstances, there is a much lower chance of these healing, but trying a rehabilitation program to allow the knee to have less chance of getting stiff after surgery may be indicated and there are some instances where these could potentially heal