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In addition, tumor cells secrete vascular endothelial growth factor (VEGF) to recruit TAMs, which become a major source of angiogenic factors via NF-B and STAT3 activation (92)

Regulates melanin transfer, boosts collagen, and reduces moisture loss

At the same time, it has been shown that melatonin supplementation can positively affect fertility and improve the effectiveness of assisted reproductive protocols (25), which may be related to its influence on the increase of melatonin concentration in the follicular fluid (25, 98)