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KLOW is not an FDA-approved treatment, and no KLOW cycle has been clinically validated

Absence of a biological response to ACTH may thus be due to impaired binding of ACTH to its receptors or inability of the bound ACTH to initiate its post-receptor effects (62-65)

A man with healthy B12 levels but uncontrolled diabetes, severe cardiovascular disease, or untreated depression may still experience sexual difficulties