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IHC results showed increased PGC-1 expression in the centrilobular hepatocytes after AMSCs treatment in Ddit4 fl/fl mice, while DDIT4 knockout reversed the effect of AMSCs administration (Fig

On the other hand, the K63-linked polyubiquitin chain participates in endosomal trafficking, signal transduction and DNA repair but not in protein degradation 2,3,10