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Effective of several NPs in reducing ROS Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made

Ethics declarations Competing interests The Johns Hopkins University has filed patent applications related to technologies described in this paper on which S.P., T.D.N., B.V., K.W.K., N.P

10.1007/s00167-018-5321-8 Knee Surg

Being a mediator of protein oxidation and nitration, lipid peroxidation, mitochondrial dysfunction, and cell death, peroxynitrite represents both a pathophysiologically relevant endogenous cytotoxin and a cytotoxic effector against invading pathogens [99]