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The screening of polyketide metabolites is a good illustration of the efficiency with a hit rate of 0.3% (more than 20 commercial drugs in just over 7000 known structures), while the hit rate for HTS of synthetic compound libraries is less than 0.001% (Weissman and Leadlay, 2005)

A previous cost minimization analysis from UK prescribing patterns and costs, revealed that switching patients to oral B12 from the IM route could lead to 50% cost savings (Vidal-Alaball et al., 2006)

In non-clinical models, research teams use this compound to examine how nicotinamide metabolism and methylation processes may influence energy expenditure signals, lipid storage markers, and metabolic communication readouts