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There are also several other underappreciated cerebellar afferent pathways (e.g., cerebellar connections with the brainstem nuclei [32]) and efferent connections (e.g., from the periaqueductal gray [33]) that we will not discuss here, but suffice it to say that cerebellar stimulation almost certainly affects many more circuits than the output pathways to the thalamus

It activates genes associated with tissue remodeling while suppressing genes linked to inflammation and tissue breakdown

The biggest drivers are sun exposure, heat, harsh or too-many skincare products, and personal flush triggers like spicy food, alcohol, and stress

Manuja et al., 2021)