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In contrast, it significantly improves anti-PD-1 responses in PD-1 refractory microsatellite stable CRC

Specifically, free ferric iron is shuttled into cells bound by transferrin (TF), and reduced to ferrous iron via catalyzing by endosomal six-transmembrane epithelial antigen of prostate 3 (STEAP3), subsequently ferrous iron is released into the cytoplasm through divalent metal transporter 1 (DMT1) to expand the labile iron pool (LIP) (Xu et al., 2024)

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Paeoniflorin attenuates hepatic ischemia/reperfusion injury via anti-oxidative, anti-inflammatory and anti-apoptotic pathways