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Hypoxic TAMs are highly glycolytic and can compete for glucose with TECs and other cells within the TME [107]

Acetyl-L-Carnitine plays an essential role in fatty acid metabolism, helping to transport long-chain fatty acids across cellular membranes and into the mitochondria to be used in the production of energy

Such injuries predominantly arise from vascular damage, manifesting within a day post-radiation and often progressing to severe tissue necrosis due to oxygen deprivation [173]

In contrast, chronic elevations in TMAO, a metabolite derived from LC, have been linked to an increased risk of atherosclerotic cardiovascular disease (ASCVD), particularly in older adults with compromised renal function [64, 65]