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Abbreviations cDNA Complementary DNA CFA Complete Freunds Adjuvant CRP C-Reactive Protein DMARDs Disease-Modifying Anti-Rheumatic Drugs DTNB Di-thio nitrobenzoic Acid EEMS Ethanolic Extract of Myxopyrum serratulum GADPH Glyceraldehyde 3-Phosphate Dehydrogenase GPX Glutathione Peroxidase GSH Glutathione IL1 Interleukin 1 iNOS Inducible Nitric Oxide Synthase MMP Matrix Metalloproteinase NSAIDs Non-Steroidal Anti-Inflammatory Drugs PPI Protein-Protein Interaction RA Rheumatoid Arthritis RANKL Receptor Activator of Nuclear Factor Kappa B Ligand RNA Ribonucleic Acid RT PCR-Reverse Transcriptase-Polymerase Chain Reaction SGOT Serum Glutamic Oxaloacetic Transaminase SGPT Serum Glutamic Pyruvic Transaminase SOD Superoxide Dismutase TCA Trichloroacetic Acid TNF Tumor Necrosis Factor VEGF Vascular Endothelial Growth Factor Author contributions Conceptualization, S.T., S.J., M.S., V.S., L.S.W., and SD

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