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The consequent changes in the ATP/ADP ratio could influence AMPK phosphorylation, thereby decelerating the tricarboxylic acid cycle (evidenced by reductions in citrate, -ketoglutarate and malate) and impairing glutathione synthesis (33, 34)

Curcumin, extracted from Radix curcumae, reduces the expression of COX-2, 5-lipoxygenase mRNA and protein in the hippocampal neurons of epileptic rats through the regulation of free radicals and carbon monoxide synthase and improves the anti-oxidative stress effect, hippocampal neuron damage, and cognitive function of pilocarp-induced epileptic in experimental rats (Yang et al., 2018)

Institute for Functional Medicine, Portland, Oregon