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However, other studies have reported conflicting findings regarding ApoE genotypes and PD risk (Federoff et al., 2012

The role of cellular protection in response to ROS accumulation has been reported, and the signal of preconditioning that leads to this protection was related to Hormesis, which means a dose-response relationship of ROS, at low levels, generates a stimulus of neurodegenerative diseases, while its accumulation (high concentration) generates an inhibition of the effect through preconditioning [21-23]

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Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology