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Muscle as an endocrine organ: focus on muscle-derived interleukin-6

A systematic review examining the relationship between an exercise-induced increase in core body temperature and intestinal permeability demonstrated that the magnitude of exercise-induced hyperthermia correlated with increased intestinal permeability (Pires et al., 2017)

In addition, consuming pre-formed glutathione is an inefficient way to raise cellular levels of glutathione since published clinical studies demonstrate that it may take weeks or months to impact cellular levels when elevated levels are most needed acutely