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The T370A substitution has no significant effect on DAMGO-induced MOR internalization while it inhibits endocytosis triggered by PKC activation (Illing et al., As demonstrated for MOR, the phosphorylation-deficient DOR mutant (T358A/T361A/S363G) is able to undergo internalization upon DPDPE activation but to a lesser extent than the wild type (Zhang et al., 2005)