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Potential nonlinear relationships were explored by generalized additive models (GAMs) with logit link functions with a cubic regression spline and a basis dimension of k = 10 for gestational weeks, and internal validation was performed by 10-fold cross-validation, to accommodate potential nonlinear relationships and interaction effects between UA and other linear confounders

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Notably, the regulatory network between lactylation and acetylation modifications likely extends beyond currently identified factors such as HDACs, histone acetyltransferase p300, and AARS1/2, suggesting the potential existence of additional regulatory components awaiting discovery

Toxin Exposure: Pesticides, heavy metals, and air pollutants increase oxidative burden