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For example, at a high BAC (~0.81.0 g/L), alcohol inhibited the hepatic first-pass metabolism of amitriptyline (TCA), which markedly increased amitriptyline plasma concentrations (274)

doi:10.1038/s41598-021-82736-w Papan C, Kremp L, Wei C, Petzold A, Schroten H, Tenenbaum T