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The second trial (NCT03611530) is comparing the time to disease progression between patients receiving placebo and those using eye drops containing both CoQ10 and vitamin E (142)

10.1002/bem.10023 71 ManniV.LisiA.RietiS.SerafinoA.LeddaM.GiulianiL.et al

This is what the mechanistic description and variant should be based on ARG treated as a form that may change stability or formulation parameters, but requires separate validation

These persister cells exhibit a reversible, non-genetic phenotypic trait unrelated to heritable drug resistance mutations, with their progeny restoring wild-type antifungal susceptibility, and the biofilm-specific niche is confirmed to be essential for their formation (LaFleur et al., 2006)