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Because both the crystal and AlphaFold-predicted structures did not exhibit the possibility of the presence of D10 to stabilize H237, and D10 is a part of the oxyanion hole, we assumed that the D10A mutant altered the conformation of the oxyanion hole loop

Although the field increasingly recognizes that the M1/M2 dichotomy is an oversimplification, since macrophages in vivo rarely exist as pure M1 or M2 states, it remains clinically useful to distinguish tumor-restraining from tumor-promoting functional programs [75,76]

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