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Experimental studies in rat models have shown that the activity of the 20S proteasome decreases with age, which is accompanied not only by a reduction in its quantity but also by changes in the composition and structure of its subunits

New England Journal of Medicine 369 (Aug 1): 438-441

This mechanism involves oncogenic Kras-induced inflammation leading to fungal dysbiosis, which subsequently activates the mannose-binding lectin C3 (MBL-C3) cascade and accelerates tumor growth (211)

A prospective, IRB-approved protocol with informed consent facilitated enrollment of 154 consecutive MASLD patients presenting to the Hepatology Clinic between November 2020 and May 2022 for simultaneous LSM and SSM measurements