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Because of the redox activity of the labile iron pool, it is thought to contribute to oxidative stress during iron overload (Piloni et al., 2016[345])

Kim DW, Tan EY, Jin Y et al , Effects of imatinib mesylate on the pharmacokinetics of paracetamol (acetaminophen) in Korean patients with chronic myelogenous leukaemia

When AGEs bind to RAGE, they trigger: Cytokine and growth factor release (e.g., TGF- and VEGF), leading to basement membrane thickening and diabetic retinopathy