local glutathione reperfusion administration Frontiers Ferroptosis in organ ischemia–reperfusion injuries:

Disclosures: Toby Bradford: Nothing to Disclose, Natalie Torok: Nothing to Disclose 618 THE LIPIDOMIC PROFILE DISCRIMINATES BETWEEN METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE AND COMBINED METABOLIC DYSFUNCTION- AND ALCOHOL-RELATED STEATOTIC LIVER DISEASE Carolin Victoria Schneider 1 Rohit Loomba 2 Helen Huang 1 Anastasia Raptis 1 Kate Townsend Creasy 3 Jan Clusmann 1 Felix Van Haag 1 Tom Luedde 4 Sven Francque 5 Kai Markus Schneider 6 , 1 RWTH Aachen, 2 University of California, San Diego, 3 University of Pennsylvania, 4 University Hospital Duesseldorf, Heinrich Heine Universitt, 5 InflaMed Centre of Excellence, Laboratory for Experimental Medicine and Paediatrics, Translational S, 6 University Hospital Aachen Background: The recent multi-society Delphi consensus statement revised the nomenclature of steatotic liver disease to replace non-alcoholic fatty liver disease

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NAMPT inhibition by FK866 is important, leading to NAD + depletion, which causes a reduction in glucose uptake, ATP production, fatty acid synthesis, an increase in ROS levels and affects the activity of all NAD + -dependent enzymes, such as sirtuins and PARPs

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