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The accuracy of the Shared Savings Program's determination of an ACO's financial performance (through a process referred to as financial reconciliation) in terms of the ACO's eligibility for and amount of a shared savings payment or liability for shared losses, depends on the accuracy of claims data

Immune dysregulationparticularly involving T-helper cell imbalance, increased pro-inflammatory cytokines (e.g., TNF-, IL-6), and reduced regulatory T cell functionhas been shown to impair maternal-fetal tolerance

On the basis of the crystal structure of the inactivated human enzyme and stopped-flow kinetic studies with two- and four-electron-reduced forms of the unreacted P