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483,484,485 PPAR- agonists (thiazolidinediones and TZDs) used for diabetes mellitus, which enhance adipocyte lipid storage, decrease ectopic lipid accumulation and improve insulin sensitivity in liver and skeletal muscles

Treatment response typically becomes apparent after 3-4 months, with maximum benefits observed after 12-24 months of consistent use

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He went on to conclude that even though the presence of senile plaques and neurofibrillary tangles were observed, the plaques are not the cause of senile dementia, but only an accompanying feature of senile involution of the central nervous system [7]