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A separate meta-analysis that pooled results of trials in older adults with mild cognitive impairment found B-vitamin supplementation (6 to 24 months, depending on the trial) had no benefits on various cognitive parameters, including executive function, information processing speed, and episodic memory (90)

Reduces Fatigue: Many patients report increased energy levels, allowing for more productive workouts and improved daily functioning

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Further studies using double knockout mice and/or co-immunoprecipitation/proximity ligation assay are required to definitively establish the presence of hybrid receptor and the requirement for both IR and IGF-1R in this process